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Table 1 The list of covariates used in analyses

From: Country-specific determinants for COVID-19 case fatality rate and response strategies from a global perspective: an interpretable machine learning framework

Short name

Dimension

Definition

Temporal coverage

Data source

Missing

Median (IQR)

Fully vaccinated

Vaccination coverage

Proportion of the population completing the initial vaccination protocol within six months

2020–2022

Our World in Data [22]

0/156

27.3 (11.4–40.0)

Booster given

 

Proportion of the population that received a booster dose within six months

2020–2022

Our World in Data [22]

0/156

3.9 (0–18.6)

Aged 65 + 

Demographic characteristics

Proportion of population aged 65 and over

2017

UN Population Division [45]

3/156

6.6 (3.5–14.7)

Gender ratio

 

Number of males born per 100 females

2020

World Development Indicators—World Bank [46]

0/156

105.1 (103.9–105.9)

Average years of schooling

 

Average number of years the population older than 25 participated in formal education

2017

Our World in Data [47]

2/156

9.2 (6.3–11.3)

GDP per capita

 

Per capita gross domestic product, a measure of a country's economic output per person

2018

World Bank [48]

4/156

13,567.3 (4796.5–28,942.6)

Lower respiratory infections

Disease burden

Age-standardised prevalence of lower respiratory infections per 100,000 population

2019

Global Burden of Disease Study 2019 [49]

0/156

130.7 (84.2–184.6)

Upper respiratory infections

 

Age-standardised prevalence of upper respiratory infections per 100,000 population

2019

Global Burden of Disease Study 2019 [49]

0/156

3228 (2774–3712)

Chronic obstructive pulmonary disease

 

Age-standardised prevalence of chronic obstructive pulmonary disease per 100,000 population

2019

Global Burden of Disease Study 2019 [49]

0/156

2054.3 (1713.3–2665.0)

Cardiovascular diseases

 

Age-standardised prevalence of cardiovascular diseases per 100,000 population

2019

Global Burden of Disease Study 2019 [49]

0/156

6477 (5616–7132)

Stroke

 

Age-standardised prevalence of stroke per 100,000 population

2019

Global Burden of Disease Study 2019 [49]

0/156

1233.6 (958.2–1411.3)

Cancers

 

Age-standardised prevalence of cancers per 100,000 population

2019

Global Burden of Disease Study 2019 [49]

0/156

6157 (4421–9517)

Diabetes

 

Age-standardised prevalence of diabetes per 100,000 population

2019

Global Burden of Disease Study 2019 [49]

0/156

5490 (4243–7292)

Chronic kidney disease

 

Age-standardised prevalence of chronic kidney disease per 100,000 population

2019

Global Burden of Disease Study 2019 [49]

0/156

7871 (6384–9957)

Hypertension

 

Prevalence of hypertension among adults aged 30–79 years

2019

Global Burden of Disease Study 2019 [49]

1/156

37.3 (31.6–42.1)

Mental disorders

 

Age-standardised prevalence of mental disorders per 100,000 population

2019

Global Burden of Disease Study 2019 [49]

0/156

12,651 (11,365–13,971)

Noncommunicable diseases

 

Age-standardised total mortality from noncommunicable diseases per 100,000 population

2019

WHO [50]

0/156

90,447 (89,596–91,749)

HIV

 

Age-standardised prevalence of HIV infection per 100,000 population

2019

Global Burden of Disease Study 2019 [49]

0/156

176.8 (46.4–589.7)

Tuberculosis

 

Age-standardised prevalence of tuberculosis per 100,000 population

2019

Global Burden of Disease Study 2019 [49]

0/156

19,036 (13,148–24,781)

Overweight

Behavioural risk factor

Prevalence of overweight among adults, BMI ≥ 25 (age-standardized estimate) (%)

2016

WHO [51]

2/156

55.6 (30.9–60.6)

Low physical activity

 

Disability-adjusted life years attributed to low physical activity

2019

Global Burden of Disease Study 2019 [49]

0/156

188.2 (134.2–330.3)

Smoking

 

Disability-adjusted life years attributed to smoking

2019

Global Burden of Disease Study 2019 [49]

0/156

2024.9 (1517.8–2721.2)

Dietary risks

 

Disability-adjusted life years attributed to dietary risks

2019

Global Burden of Disease Study 2019 [49]

0/156

2210.2 (1607.3–2950.3)

Trees per capita

Environmental risk factor

Number of trees per capita

2014

Mapping tree density at a global scale [52]

0/156

191.0 (52.2–695.8)

PM2.5

 

Population-weighted exposure to ambient PM2.5 pollution (μg/m3) is defined as the average level of exposure of a nation's population to concentrations of suspended particles measuring less than 2.5 microns in aerodynamic diameter, which are capable of penetrating deep into the respiratory tract and causing severe health damage

2017

Global Burden of Disease Study 2019 [49]

1/156

22.2 (14.5–36.7)

Mean temperature

 

Mean temperature (Celsius)

1991–2020

World Bank Climate Change Knowledge Portal [53]

0/156

22.1 (11.3–25.5)

Population density

 

Population density (people per sq. km of land area)

2020

World Bank [54]

1/156

81.7 (31.8–160.8)

HAQ index

Health service

Healthcare Access and Quality Index

2018

GBD 2016 Healthcare Access and Quality Collaborators [32]

8/156

66.8 (41.5–81.0)

IHR score

 

Average of 13 International Health Regulations core capacity scores, 1st version of the questionnaire

2019

WHO [55]

0/156

66.5 (49.8–83.0)

Hospital beds

 

The number of hospital beds available per 10,000 inhabitants

2017

WHO [56]

3/156

20.6 (10.0–36.0)

Expenditure

 

Current health expenditure per capita in US$

2019

WHO [57]

4/156

392.5 (75.2–1407.3)

Hospitals

 

Total density of hospitals per 100,000 population

2013

WHO [58]

49/156

1.0 (0.5–1.8)

Trust the national government

Trust

Trust in the national government of the country

2020

Wellcome Global Monitor Survey [59]

55/156

52.5 (43.0–69.5)

Trust journalists

 

Trust in journalists in this country

2020

Wellcome Global Monitor Survey [59]

51/156

55.2 (47.4–64.8)

Trust science

 

Trust in science

2020

Wellcome Global Monitor Survey [59]

50/156

80.5 (70.0–88.8)

  1. GDP, gross domestic product; PM2.5: particles measuring less than 2.5 microns in aerodynamic diameter; HAQ, Healthcare Access and Quality Index; IHR, International Health Regulations core capacity; WHO, World Health Organization