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Table 2 Sequential multilevel Poisson regression models for individuals with a SARS-CoV-2 infection in Ontario

From: Quantifying the magnitude of the general contextual effect in a multilevel study of SARS-CoV-2 infection in Ontario, Canada: application of the median rate ratio in population health research

Distinct Areas (i.e., FSA) = 513

Individuals (Numerator) = 342 729

Population (Denominator) = 11 762 208

Model I (Null model)

Model II

(Model I + age, sex, and chronic conditions)

Model III

(Model II + census-based area measures)

Intercept

2.97

2.39

2.86

Individual Level

RR (95% CI)

RR (95% CI)

RR (95% CI)

Age, yr

   

 20–34

 

2.24 (2.18–2.31)

2.24 (2.18–2.31)

 35–49

 

1.84 (1.79–1.89)

1.84 (1.79–1.89)

 50–64

 

1.65 (1.62–1.68)

1.65 (1.62–1.68)

 65–114

 

1.00

1.00

Sex (ref. male)

 

1.00 (0.99–1.01)

1.00 (0.99–1.01)

Diabetes

 

1.29 (1.27–1.32)

1.29 (1.27–1.32)

Hypertension

 

1.09 (1.08–1.10)

1.09 (1.08–1.10)

COPD

 

0.94 (0.92–0.96)

0.94 (0.92–0.96)

CHF

 

1.20 (1.16–1.24)

1.20 (1.16–1.24)

Asthma

 

1.03 (1.01–1.05)

1.03 (1.01–1.05)

FSA census-based variables

RR (95% CI)

RR (95% CI)

RR (95% CI)

Household size

  

1.83 (1.71–1.97)

Proportion of people driving to work

  

0.68 (0.65–0.71)

Proportion of people in sales / service Jobs

  

1.13 (1.06–1.21)

Median after-tax income in 2015

  

0.96 (0.89–1.02)

Level 2 (FSA) Variance of Random Effect

0.61

0.58

0.29

Proportional change in variance (PCV) by the new model (%)

Reference

4.92

52.46

Median Rate Ratio

2.1

2.07

1.67

Median Rate Ratio attenuation (%)

Reference

2.73

39.09

Model Fit Statistics

   

Deviance (-2 Log Likelihood)

178298.7

159760.8

159427.7

Dispersion (Pearson Chi-Square / DF)

1.27

1.04

1.04

AIC

178302.7

159782.8

159457.7

BIC

178311.1

159829.4

159521.3

  1. Abbreviation FSA, forward sortation area; RR, incidence rate ratio; CI, confidence interval; yr, year; ref., reference; COPD, chronic obstructive pulmonary disease; CHF, congestive heart failure; DF, degrees of freedom; AIC, Akaike information criterion; BIC, Bayesian information criterion
  2. Note The area was defined according to forward sortation areas (FSA). In Canada, the FSA is a geographic region based on the first three characters of the six character Canadian postal code. The FSA census-based variables were standardized to a mean of 0 and a standard deviation of 1. The patients in this study had a SARS-CoV-2 infection in Ontario, Canada between March 1, 2020, and May 1, 2021. The reported intercepts are not exponentiated. The incidence rate ratio for test positive SARS-CoV-2 infection is per 1000 people