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Table 2 Baseline characteristics of participants

From: NPR is an independent risk factor for predicting all-cause mortality in patients with metabolic dysfunction-associated steatotic liver disease: evidence from NHANES 2007–2020

Characteristics

Overall (n = 8051)

Non MASLD (n = 5380)

MASLD (n = 2671)

P

MASLD without ALF (n = 2154)

MASLD with ALF (n = 517)

P

Age, n (%)

39(29,53)

36(27,47)

45(34,60)

 < 0.001

43(33,56)

66(55,74)

 < 0.001

Gender, n (%)

   

 < 0.001

  

 < 0.001

Male

5,570(67.9%)

3,429(62.4%)

2,141(80.0%)

1,669(78.38%)

472(88.85%)

Female

2,481(32.1%)

1,951(37.6%)

530(20.0%)

485(21.62%)

45(11.15%)

Ethnicity, n (%)

   

 < 0.001

  

 < 0.001

Mexican American

1,260(9.8%)

633(7.4%)

627(15.0%)

560(16.50%)

67(6.90%)

Non-Hispanic White

3,350(65.2%)

2,164(64.4%)

1,186(67.0%)

899(65.39%)

287(75.43%)

Non-Hispanic Black

1,610(11.0%)

1,299(13.2%)

311(6.0%)

228(5.67%)

83(7.63%)

Other Race

1,831(14.0%)

1,284(15.0%)

566(12%)

467(12.44%)

80(10.04%)

PIR

3.0(1.4, 5.0)

3.1(1.5, 5.0)

2.7(1.4, 4.8)

0.022

2.73(1.31, 4.83)

2.72(1.61, 4.91)

0.3

Education, n (%)

   

 < 0.001

  

0.9

Less than high school

1,813(15.7%)

1,061(13.7%)

752(20.0%)

616(20.13%)

136(19.10%)

High school

1,791(21.9%)

1,176(21.2%)

615(23.4%)

490(23.34%)

125(23.57%)

College or more

4,447(62.4%)

3,143(65.1%)

1,304(56.6%)

1,048(56.52%)

256(57.33%)

Physical measurement

BMI (kg/m2)

27.6(24.0, 31.9)

25.7(22.9, 28.7)

32.9(29.4, 37.2)

 < 0.001

32.6(29.2, 36.5)

36.0(30.8, 44.2)

 < 0.001

Disorders or status

Smoking, n (%)

3,687(44.99%)

2,324(42.71%)

1,363(50.03%)

 < 0.001

1,050(48.26%)

313(59.92%)

 < 0.001

T2DM, n (%)

1,258(10.89%)

426(4.91%)

832(24.13%)

 < 0.001

558(19.71%)

274(48.93%)

 < 0.001

Hypertension, n (%)

3,648(40.62%)

1,925(30.40%)

1,723(63.23%)

 < 0.001

1,292(59.84%)

431(82.22%)

 < 0.001

Hyperlipidemia, n (%)

4,703(57.13%)

2,686(48.84%)

2,017(75.44%)

 < 0.001

1,627(75.90%)

390(72.89%)

0.3

Laboratory indicators

ALT (U/L)

21(16, 29)

19(15, 25)

28(21, 38)

 < 0.001

29(22, 39)

23(17, 30)

 < 0.001

SCr (mg/dL)

0.88(0.74, 1.01)

0.87(0.73, 1.00)

0.90(0.77, 1.03)

 < 0.001

0.88(0.76, 1.01)

1.01 (0.84, 1.21)

 < 0.001

Neutrophil count

(× 103cells/ul)

3.7(2.9, 4.8)

3.5(2.8, 4.5)

4.1(3.4, 5.2)

 < 0.001

4.1(3.4, 5.2)

4.2(3.4, 5.2)

0.5

Monocyte count

(× 103cells/ul)

0.5(0.4, 0.6)

0.5(0.4, 0.6)

0.6(0.5, 0.7)

 < 0.001

0.6(0.5, 0.7)

0.6(0.5, 0.7)

0.4

HDL (mg/dL)

49(41, 59)

53(44, 63)

43(37., 49)

 < 0.001

43(37, 49)

43(36, 50)

0.9

Neutrophil-associated inflammatory markers

NPR

0.016

(0.013,0.021)

0.015

(0.012,0.020)

0.018

(0.014,0.023)

 < 0.001

0.017

(0.014, 0.021)

0.024

(0.018, 0.031)

 < 0.001

NHR

0.08(0.05, 0.10)

0.07(0.05, 0.09)

0.10(0.07, 0.13)

 < 0.001

0.10(0.07, 0.13)

0.10(0.07, 0.13)

0.8

SII

440(323, 623)

421(310, 599)

484(355, 662)

 < 0.001

494(362, 669)

442(306, 635)

 < 0.001

SIRI

0.99(0.68, 1.41)

0.91(0.64, 1.32)

1.13(0.81, 1.61)

 < 0.001

1.10(0.80, 1.56)

1.31(0.95, 2.00)

 < 0.001

  1. *Continuous variables are represented by Median (IQR)), while categorical variables are denoted by unweighted n (%). Bold values indicate statistical significance at P<0.05. Abbreviation: PIR, family poverty income ratio; BMI, body mass index; T2DM, type 2 diabetes mellitus; ALT, alanine aminotransferase; Scr, serum creatinin; HDL-C, high density lipoprotein cholesterol; NPR, neutrophil to platelet ratio; NHR, neutrophil to HDL-C cholesterol ratio; SII, systemic immune-inflammation index; SIRI, systemic inflammatory response index
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