NPR is an independent risk factor for predicting all-cause mortality in patients with metabolic dysfunction-associated steatotic liver disease: evidence from NHANES 2007–2020

Table 3 The relationship between neutrophil-associated inflammatory index with the risk of MASLD and ALF

Characteristics (ln-transformed)	Model 1¹		Model 2²		Model 3³
Characteristics (ln-transformed)	OR (95% CI)	P	OR (95% CI)	P	OR (95% CI)	P
MASLD
NPR	2.58(2.10,3.04)	< 0.001	2.10(1.78,2.48)	< 0.001	1.63(1.35,1.97)	< 0.001
NHR	5.82(4.94,6.86)	< 0.001	5.74(4.83,6.83)	< 0.001	3.03(2.44,3.77)	< 0.001
SII	1.63(1.43,1.86)	< 0.001	1.59(1.38,1.83)	< 0.001	1.36(1.12,1.64)	0.002
SIRI	1.86(1.69,2.04)	< 0.001	1.52(1.37,1.69)	< 0.001	1.36(1.17,1.58)	< 0.001
ALF
NPR	12.15(8.54,17.28)	< 0.001	9.91(6.80,14.44)	< 0.001	10.93(6.76,17.65)	< 0.001
NHR	1,04(0.73,1.48)	0.800	1.24(0.83,1.86)	0.300	0.58(0.32,1.03)	0.060
SII	0.66(0.51,0.86)	< 0.001	0.56(0.40,0.80)	0.002	0.22(0.11,0.45)	< 0.001
SIRI	1.98(1.56,2.51)	< 0.001	1.21(0.93,1.58)	0.200	0.72(0.53,0.98)	0.040

¹The model 1 was not adjusted for any covariates
²The model 2 was adjusted for age, gender, and race
³The model 3 was adjusted for all covariates based on model 1
Bold values indicate statistical significance at P<0.05. MASLD, metabolic dysfunction-associated steatotic liver disease; ALF, advanced liver fibrosis; NPR, neutrophil to platelet ratio; NHR, neutrophil to HDL-C cholesterol ratio; SII, systemic immune-inflammation index; SIRI, systemic inflammatory response index

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